Aging Effects of MMN

Tark, Pyungkon; Kim, Jinsook

ORIGINAL ARTICLE

Commun Sci Disord. 2002;7(1): 203-213.

Pyungkon Tark^` , and Jinsook Kim^`

탁평곤(Pyungkon Tark)| 김진숙(Jinsook Kim)

ABSTRACT

Deviant tones randomly embedded in a sequence of standard tones elicit event - related potentials (ERPs) called the Mismatch Negativity (MMN), which reflect automatic stimuluschange detection in the human auditory system. The MMN was measured of 10 adult s (18- 24 year s) and 6 elder s (45-60 years) with normal hearing to determine the effect of aging on the auditory evoked potential. Each subject was instructed not to attend to tones by singing three songs. The tones were binaurally presented to the subject in a random order (probability of 0.2 for deviant s). A 750 Hz tone with 1-36- 1 cycle served as the standard tone. The deviant tones were similar to the standard except for the 1000Hz frequency (1-48- 1 cycle). Interstimulus interval was 800ms. The MMN peak latency and onset latency of the elder group were 268 ms and 207.33ms, respectively. The MMN peak latency and onset latency of the younger group were 209ms and 171.00ms, respectively. The MMN latencies significantly increased with aging (p < 0.05). However, the MMN amplitude of the elder group was - 2.24 V and that of the younger group was - 2.26 V. The amplitude effect was insignificant (p > 0.05). These findings imply that the younger group detects the difference between the two tones faster than the elder group.

Keywords: MMN | 사건관련전위 | 차이파형 | 초기잠복기