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Commun Sci Disord. 2010;15(4): 537-548.
Characteristics of Respiration and Phonation in Patients with Young-Onset Parkinson’s Disease Compared to Normal Adults
Eun Ae Chun` , Young Ho Shon` , Seung Jae Baek` , Phil Hyu Lee` , Chung Mo Nam` , Ji Eun Lee` , and Yaelin Choi`
Copyright ©2010 The Korean Academy of Speech-Language Pathology and Audiology
전은애(Eun Ae Chun)|손영호(Young Ho Shon)|백승재(Seung Jae Baek)|이필휴(Phil Hyu Lee)|남정모(Chung Mo Nam)|이지은(Ji Eun Lee)|최예린(Yaelin Choi)
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Background & Objectives
Parkinson’s disease affects respiration as well as phonation. Young-onset Parkinson’s disease (YOPD) can occur even before the age of 49 years. The present study selected YOPD patients in such a manner as to exclude the confounding variable of ‘age’ and thus examine the vocal characteristics of Parkinson’s disease solely. We aimed to compare the respiration function and phonation characteristics of these YOPD patients with a normal group.
The present study’s subjects included a YOPD group comprised of 6 patients whose chronological ages were between 38 and 49 years and onset ages were prior to 49 years, and a normal group comprised of 6 subjects selected by frequency-matching. For testing respiration function, FVC, FEV1 and FEV1/FVC were measured using Cosmed’s MicroQuarkⓇ as a basic test for the ventilation function of the lung. For vocal sampling, the Multi-Dimensional Voice Program (MDVP) and the Advanced Model 5105 of KayPENTAX’s Computerized Speech Lab (CSL) Model 4400 were used to analyze maximum phonation time (MPT), jitter, and shimmer. Additionally, KayPENTAX’s Phonatory Aerodynamic System (PAS) 4500 was utilized to analyze mean air flow rate (MFR) and subglottal pressure (Psub). Otolaryngologists and neurologists participated in the research cooperatively, and the otolaryngologists assessed the presence of laryngeal disease directly through larynx stroboscopy in the all subject. Mann-Whitney’s U test was used to analyze the difference between the 2 groups’ respiration and phonation function.
The MPT was longer in the normal group than YOPD patient group, and both jitter and shimmer were larger in the YOPD patient group than the normal group; both of these differences were statistically significant. However, there was no statistically significant difference in FVC, FEV1, FEV1/FVC, MFR, and Psub.
Discussion & Conclusion
The 2 groups’ respiration function did not differ, and YOPD patients’ MPT, jitter, and shimmer differed beyond the normal range. Thus, these variables will help in YOPD patients’ phonation diagnosis and therapeutic plans or prognosis. Although there have been studies on the phonation of Parkinson’s disease patients, limited advanced research can be found on the respiration and phonation function of YOPD patients’ vocal characteristics. The results of this study are meaningful and provide a better understanding of Parkinson’s disease because the subjects were selected such that confounding by age was avoided.
Keywords: 조기발병형 파킨슨병 | 호흡기능 | 최대발성지속시간 | 평균호기류율 | 성문하압 | 주기간 주파수 변동률 | 주기간 진폭 변동률
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